Factor Viia (recombinant) (novoseven®) in Trauma
ثبت نشده
چکیده
EVIDENCE DEFINITIONS • Class I: Prospective randomized controlled trial. • Class II: Prospective clinical study or retrospective analysis of reliable data. Includes observational, cohort, prevalence, or case control studies. • Class III: Retrospective study. Includes database or registry reviews, large series of case reports, expert opinion. • Technology assessment: A technology study which does not lend itself to classification in the above-mentioned format. Devices are evaluated in terms of their accuracy, reliability, therapeutic potential, or cost effectiveness.
منابع مشابه
[Adjunct use of NovoSeven (recombinant factor VIIa) for penetrating cardiac trauma].
BACKGROUND Uncontrolled bleeding leads to 40-86% of preventable deaths due to trauma. Use of NovoSeven (rFVIIa) in trauma is promising, although data supporting its utilization are limited. CASE REPORT We report the case of a patient who sustained a penetrating grade V cardiac injury (AAST-OIS) and presented postoperative massive coagulopathic bleeding arrested by the administration of platel...
متن کاملNovoSeven: Cleveland Clinic Guidelines
In This Issue: • NovoSeven • Therapeutic Interchanges Introduction: Recombinant human activated Factor VII (rFVIIa), or NovoSeven, is a hemostatic agent which is structurally similar to human plasma-derived coagulation Factor VIIa. Recombinant FVIIa is currently licensed by the US Food and Drug Administration (FDA) in patients with hemophilia A or B with inhibitors to Factor VIII or Factor IX o...
متن کاملThe effect of recombinant factor VIIa (NovoSeven(R)) on peri-operative bleeding during total knee replacement in a non-hemophiliac patient.
Background. Recombinant factor VIIa has been in use for some time to control bleeding in persons with hemophilia. In the present study we describe our experience with the use of a commercial form of recombinant factor VIIa, NovoSeven(R) (Novo Nordisk, Denmark), to control perioperative bleeding in the course of total knee replacement on a patient who, though not hemophiliac, had a very low tole...
متن کاملCorrection: Clinical experiences and current evidence for therapeutic recombinant factor VIIa treatment in nontrauma settings
Following the publication of the above article [1], we noticed that the Competing interests section was incorrect and should read as follows: RMG has worked as a consultant for Novo Nordisk and lectured on behalf of Novo Nordisk about NovoSeven. References 1. Grounds RM, Bolan C: Clinical experiences and current evidence for therapeutic recombinant factor VIIa treatment in nontrauma settings.
متن کاملRecombinant activated factor VIIa and hemostasis in critical care: a focus on trauma
In this article we describe the current use of recombinant activated factor VII (rFVIIa; NovoSeven) in trauma patients. Emphasis is placed on current uses as defined by key studies, efficacy data, and safety data. Most published studies in trauma patients are retrospective case studies and reports, although an international, double-blind, randomized, controlled, phase II study has been conducte...
متن کامل